Required Readings

Neurological:

Devlin JW, et al. Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU. Crit Care Med. 2018 Sep;46(9):e825-e873. doi: 10.1097/CCM.0000000000003299. PMID: 30113379.

Cardiovascular

Russell JA. Vasopressor therapy in critically ill patients with shock. Intensive Care Med. 2019 Nov;45(11):1503-1517. doi: 10.1007/s00134-019-05801-z. Epub 2019 Oct 23. PMID: 31646370.

Semler MW, et al; SMART Investigators and the Pragmatic Critical Care Research Group. Balanced Crystalloids versus Saline in Critically Ill Adults. N Engl J Med. 2018 Mar 1;378(9):829-839. doi: 10.1056/NEJMoa1711584. Epub 2018 Feb 27. PMID: 29485925; PMCID: PMC5846085.

Pulmonary

Basics of mechanical ventilation: Daoud EG, Shimabukuro R. Mechanical ventilation for the non-critical care trained practitioner. Part 1. J Mech Vent 2020; 1(2):39-51. doi.org/10.53097/JMV.10011

Gorman EA, et al. Acute respiratory distress syndrome in adults: diagnosis, outcomes, long-term sequelae, and management. Lancet. 2022 Oct 1;400(10358):1157-1170. doi: 10.1016/S0140-6736(22)01439-8. Epub 2022 Sep 4. PMID: 36070788.

Renal

Griffin BR, et al. Critical Care Nephrology: Core Curriculum 2020. Am J Kidney Dis. 2020 Mar;75(3):435-452. doi: 10.1053/j.ajkd.2019.10.010. Epub 2020 Jan22. PMID: 31982214; PMCID: PMC7333544.

Endocrine

Annane D, Bellissant E, Bollaert P, Briegel J, Keh D, Kupfer Y, Pirracchio R, Rochwerg B. Corticosteroids for treating sepsis in children and adults. Cochrane Database of Systematic Reviews 2019, Issue 12. Art. No.: CD002243. DOI: 10.1002/14651858.CD002243.pub4

Landmark Trials to Know

Neurology

Sedation SAT/SBT: ABC (2008)

Pulmonary

ARDS Lower tidal volumes: ARDSnet 2000 (2000)

ARDS Paralytics: ACURASYS (2010) vs ROSE (2019)

ARDS Prone therapy: PROSEVA (2013)

ARDS Steroids: DEXA-ARDS (2020) and RECOVERY (2021)

Pulmonary embolism Alteplase for submassive PE: MOPETT (2012)

Tracheostomy Early vs. Late tracheostomy: TracMan (2013)

Cardiology

TTM after cardiac arrest: HACA (2002) and HYPERION (2019) and TTM (2013) and TTM2 (2021)

Shock- Use of Angiotensin II ATHOS-3 (2017)

Shock- Dopamine vs. Levophed: SOAP-II (2010)

Shock- ECMO benefits: EOLIA (2018)

Shock- Hydrocortisone therapy: APROCCHSS (2018)

Shock- Vasopressin and Levophed: VASST (2008) and VANISH (2016)

Abdominal/GI

Hemorrhage TXA use in GIB: HALT-IT Trial (2020)

Renal

Early vs. Delayed RRT: IDEAL-ICU (2018)

Lasix bolus vs. Infusion: DOSE (2011)

Infectious Diseases

Procalcitonin: PRORATA (2010)

Nutrition

Trophic vs. Full enteral feeds: EDEN (2012)

Glycemic control in the ICU: NICE-SUGAR (2009)